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Mouse Anti-CYP4V2 Recombinant Antibody (CBWJC-2110) (CBMAB-C2811WJ)

This product is a Mouse antibody that recognizes CYP4V2. This antibody CBWJC-2110 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all CYP4V2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2110
Antibody Isotype
IgG
Application
ELISA, IHC, WB

Basic Information

Immunogen
Peptide Sequence- KREELGLEGQ (aa95-504)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 4 Subfamily V Member 2
Introduction
CYP4V2 (Cytochrome P450 Family 4 Subfamily V Member 2) is a Protein Coding gene. Diseases associated with CYP4V2 include Bietti Crystalline Corneoretinal Dystrophy and Telangiectatic Osteogenic Sarcoma. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.
Entrez Gene ID
285440
UniProt ID
Q6ZWL3
Alternative Names
Cytochrome P450 Family 4 Subfamily V Member 2; Cytochrome P450, Family 4, Subfamily V, Polypeptide 2; Docosahexaenoic Acid Omega-Hydroxylase CYP4V2; Cytochrome P450 4V2; EC 1.14.13.199; EC 1.14.14.1; EC 1.14.13.-; CYP4AH1; BCD;
Function
A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs (PubMed:22772592).

Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate> laurate> palmitate (C14>C12>C16) (PubMed:19661213).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Biological Process
Fatty acid omega-oxidation Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Retinoid metabolic process Source: Reactome
Sterol metabolic process Source: Reactome
Visual perception Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Bietti crystalline corneoretinal dystrophy (BCD):
An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life.
Topology
Helical: 13-33

Sharma, S., Liu, S., Durairaj, P., Machalz, D., Wolber, G., & Bureik, M. (2021). A convenient test system for the identification of CYP4V2 inhibitors. Molecular vision, 27, 601.

Wu, S., Zhu, T., Sun, Z., Wei, X., Han, X., Zou, X., & Sui, R. (2021). Generation of a human induced pluripotent stem cell line from a Bietti crystalline corneoretinal dystrophy patient with CYP4V2 mutations. Stem Cell Research, 53, 102330.

Meng, X. H., He, Y., Zhao, T. T., Li, S. Y., Liu, Y., & Yin, Z. Q. (2019). Novel mutations in CYP4V2 in Bietti corneoretinal crystalline dystrophy: Next-generation sequencing technology and genotype-phenotype correlations. Molecular Vision, 25, 654.

Zhang, X., Xu, K., Dong, B., Peng, X., Li, Q., Jiang, F., ... & Li, Y. (2018). Comprehensive screening of CYP4V2 in a cohort of Chinese patients with Bietti crystalline dystrophy. Molecular Vision, 24, 700.

Lockhart, C. M., Smith, T. B., Yang, P., Naidu, M., Rettie, A. E., Nath, A., ... & Kelly, E. J. (2018). Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. British Journal of Ophthalmology, 102(2), 187-194.

Hirashima, T., Miyata, M., Ishihara, K., Hasegawa, T., Sugahara, M., Ogino, K., ... & Yoshimura, N. (2017). Choroidal vasculature in Bietti crystalline dystrophy with CYP4V2 mutations and in retinitis pigmentosa with EYS mutations. Investigative ophthalmology & visual science, 58(10), 3871-3878.

Jiao, X., Li, A., Jin, Z. B., Wang, X., Iannaccone, A., Traboulsi, E. I., ... & Hejtmancik, J. F. (2017). Identification and population history of CYP4V2 mutations in patients with Bietti crystalline corneoretinal dystrophy. European Journal of Human Genetics, 25(4), 461-471.

Yi, M., Shin, J. G., & Lee, S. J. (2017). Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. Toxicology and applied pharmacology, 330, 100-106.

Jinda, W., Taylor, T. D., Suzuki, Y., Thongnoppakhun, W., Limwongse, C., Lertrit, P., ... & Atchaneeyasakul, L. O. (2017). Whole exome sequencing in eight Thai patients with Leber congenital amaurosis reveals mutations in the CTNNA1 and CYP4V2 genes. Investigative ophthalmology & visual science, 58(4), 2413-2420.

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For research use only. Not intended for any clinical use.

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