Sign in or Register   Sign in or Register
  |  

Mouse Anti-CYP51A1 Recombinant Antibody (CBXC-3154) (CBMAB-C0952-CQ)

This product is a mouse antibody that recognizes CYP51A1. The antibody CBXC-3154 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all CYP51A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-3154
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide NPVIRYKRRS (C-terminal sequence)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 51 Subfamily A Member 1
Introduction
CYP51A1 (Cytochrome P450 Family 51 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP51A1 include Spleen Angiosarcoma and Spleen Cancer. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and cholesterol biosynthesis I. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
Entrez Gene ID
1595
UniProt ID
Q16850
Alternative Names
Cytochrome P450 Family 51 Subfamily A Member 1; Cytochrome P450, Family 51, Subfamily A, Polypeptide 1; Cytochrome P450, 51 (Lanosterol 14-Alpha-Demethylase); Sterol 14-Alpha Demethylase; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; EC 1.14.13.70;
Function
A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid (PubMed:20149798, PubMed:8619637).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20149798, PubMed:8619637).
Biological Process
Cholesterol biosynthetic process Source: Reactome
Negative regulation of amyloid-beta clearance Source: ARUK-UCL
Negative regulation of protein catabolic process Source: ARUK-UCL
Negative regulation of protein secretion Source: ARUK-UCL
Nervous system development Source: Reactome
Regulation of lipid metabolic process Source: Reactome
Steroid biosynthetic process Source: UniProtKB
Sterol metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane
Topology
Helical: 24-44
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CYP51A1 Recombinant Antibody (CBXC-3154)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare