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Mouse Anti-DACH2 Recombinant Antibody (A-5) (CBMAB-D0165-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dachshund Family Transcription Factor 2 (DACH2). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DACH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dachshund Family Transcription Factor 2
Introduction
DACH2 contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. DACH2 is located on the X chromosome and is subject to inactivation by DNA methylation. DACH2 may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.
Entrez Gene ID
Human117154
Mouse93837
Rat302333
UniProt ID
HumanQ96NX9
MouseQ925Q8
RatF1LX95
Alternative Names
Dachshund Family Transcription Factor 2; Dachshund Homolog 2 (Drosophila); Dach2;
Function
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity).

Probably binds to DNA via its DACHbox-N domain.
Biological Process
Development of primary female sexual characteristics Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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