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Mouse Anti-DAZL Recombinant Antibody (3-11A) (CBMAB-D0277-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Deleted In Azoospermia Like (DAZL). The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all DAZL antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
3-11A
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Deleted In Azoospermia Like
Introduction
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. DAZL is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, DAZL is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.
Entrez Gene ID
Human1618
Mouse13164
Rat680486
UniProt ID
HumanQ92904
MouseQ64368
RatD4A0P8
Alternative Names
Deleted In Azoospermia Like; Deleted In Azoospermia-Like 1; Deleted In Azoospermia-Like; SPGY-Like-Autosomal; DAZ-Like Autosomal; DAZ Homolog; SPGYLA;
Function
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).
Biological Process
3'-UTR-mediated mRNA stabilization Source: GO_Central
Germ cell development Source: ProtInc
Multicellular organism development Source: UniProtKB-KW
Positive regulation of translational initiation Source: UniProtKB
Spermatogenesis Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.

Zhao, Y., Du, Y., Ge, Q., Yan, F., & Wei, S. (2022). Identification and expression analysis of Dazl homologue in Cynops cyanurus. Zygote, 30(2), 221-226.

Bertho, S., Clapp, M., Banisch, T. U., Bandemer, J., Raz, E., & Marlow, F. L. (2021). Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition. Development, 148(7), dev187773.

Yuan, Z., Luo, J., Wang, L., Li, F., Li, W., & Yue, X. (2020). Expression of DAZL gene in selected tissues and association of its polymorphisms with testicular size in Hu sheep. Animals, 10(4), 740.

Yang, C. R., Rajkovic, G., Daldello, E. M., Luong, X. G., Chen, J., & Conti, M. (2020). The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Nature communications, 11(1), 1-16.

Li, T., Wang, X., Zhang, H., Chen, H., Liu, N., Xue, R., ... & Ma, Y. (2020). Gene expression patterns and protein cellular localization suggest a novel role for DAZL in developing Tibetan sheep testes. Gene, 731, 144335.

Rosario, R., Crichton, J. H., Stewart, H. L., Childs, A. J., Adams, I. R., & Anderson, R. A. (2019). Dazl determines primordial follicle formation through the translational regulation of Tex14. The FASEB Journal, 33(12), 14221-14233.

Karaman, M., Budak, H., & Çiftci, M. (2019). Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress. Archives of physiology and biochemistry, 125(5), 447-455.

Rosario, R., Smith, R. W., Adams, I. R., & Anderson, R. A. (2017). RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary. MHR: Basic science of reproductive medicine, 23(3), 177-186.

Nailwal, M., & Chauhan, J. B. (2017). In silico analysis of non-synonymous single nucleotide polymorphisms in human DAZL gene associated with male infertility. Systems Biology in Reproductive Medicine, 63(4), 248-258.

Lee, Y. S., Jung, H. J., & Yoon, M. J. (2017). Undifferentiated embryonic cell transcription factor 1 (UTF 1) and deleted in azoospermia‐like (DAZL) expression in the testes of donkeys. Reproduction in Domestic Animals, 52(2), 264-269.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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