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Mouse Anti-DCAF8 Recombinant Antibody (CBWJW-003) (CBMAB-D0003-WJ)

This product is a mouse antibody that recognizes DCAF8. The antibody CBWJW-003 can be used for immunoassay techniques such as: WB.
See all DCAF8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJW-003
Antibody Isotype
IgM
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DDB1 And CUL4 Associated Factor 8
Introduction
DCAF8 is a protein-coding gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. The diseases associated with DCAF8 include Giant Axonal Neuropathy 2, Autosomal Dominant and Giant Axonal Neuropathy 2. An important paralog of this gene is ENSG00000258465.
Entrez Gene ID
50717
UniProt ID
Q5TAQ9
Alternative Names
GAN2; H326; WDR42A
Function
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Biological Process
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Nucleus; Cytoplasm. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.
Involvement in disease
Giant axonal neuropathy 2, autosomal dominant (GAN2):
An autosomal dominant peripheral axonal neuropathy characterized by onset of distal sensory impairment with lower extremity muscle weakness and atrophy after the second decade. Clinical features include foot deformities apparent in childhood, and cardiomyopathy in severely affected individuals. Sural nerve biopsy shows giant axonal swelling with neurofilament accumulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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