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Mouse Anti-DCBLD2 Recombinant Antibody (3G10) (CBMAB-D0326-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Discoidin, CUB And LCCL Domain Containing 2 (DCBLD2). The antibody can be used for immunoassay techniques, such as ELISA, IF.
See all DCBLD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Immunogen
DCBLD2 (NP_563615.3, 80 a.a. ~ 164 a.a) partial recombinant protein with GST tag. The immunogen sequence: ESGTLTSINY PQTYPNSTVC EWEIRVKMGE RVRIKFGDFD IEDSDSCHFN YLRIYNGIGV SRTEIGKYCG LGLQMNHSIE SKGNE
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 80-164

Target

Full Name
discoidin, CUB and LCCL domain containing 2
Introduction
DCBLD2 (Discoidin, CUB And LCCL Domain Containing 2) is a protein coding gene. Diseases associated with DCBLD2 include X-Linked Nonsyndromic Deafness. Among its related pathways are Neuroscience. And a paralog is F8.
Entrez Gene ID
131566
UniProt ID
Q96PD2
Alternative Names
Discoidin, CUB And LCCL Domain Containing 2; Endothelial And Smooth Muscle Cell-Derived Neuropilin-Like Protein; CUB, LCCL And Coagulation Factor V/VIII-Homology Domains Protein 1; CLCP1; ESDN; Coagulation Factor V/VIII-Homology Domains Protein 1; Discoidin, CUB And LCCL Domain-Containing Protein 2; 1700055P21Rik;
Biological Process
Intracellular receptor signaling pathway Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Wound healing Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 67-528
Helical: 529-549
Cytoplasmic: 550-775

Guillemin, J. A. (2021). Dcbld2 is Essential in Zebrafish Retinal Development.

Chen, X., Lv, Y., Xu, K., Wang, X., Zhao, Y., Li, J., ... & Xiang, R. (2021). DCBLD2 mediates epithelial-mesenchymal transition-induced metastasis by cisplatin in lung adenocarcinoma. Cancers, 13(6), 1403.

Feng, Z., Li, K., Wu, Y., & Peng, C. (2021). Transcriptomic profiling identifies DCBLD2 as a diagnostic and prognostic biomarker in pancreatic ductal adenocarcinoma. Frontiers in molecular biosciences, 8, 194.

Alhamoudi, K. M., Barhoumi, T., Al-Eidi, H., Asiri, A., Nashabat, M., Alaamery, M., ... & Alfadhel, M. (2021). A homozygous nonsense mutation in DCBLD2 is a candidate cause of developmental delay, dysmorphic features and restrictive cardiomyopathy. Scientific Reports, 11(1), 1-12.

Xie, P., Yuan, F. Q., Huang, M. S., Zhang, W., Zhou, H. H., Li, X., & Liu, Z. Q. (2021). DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance. Frontiers in Cell and Developmental Biology, 9, 1279.

Cheng, S., Wang, L. Y., Wang, C. H., Wang, F. K., Zhu, B., Zhang, P., & Wang, G. H. (2021). Transmembrane protein DCBLD2 is correlated with poor prognosis and affects phenotype by regulating epithelial-mesenchymal transition in human glioblastoma cells. NeuroReport, 32(6), 507-517.

He, J., Huang, H., Du, Y., Peng, D., Zhou, Y., Li, Y., ... & Nie, Y. (2020). Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer. Cellular Oncology, 43(3), 409-420.

Chen, X., Lv, Y., Huang, C., & Xiang, R. (2020). DCBLD2 mediated cisplatin-induced epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer.

Schmoker, A. M., Weinert, J. L., Kellett, K. J., Johnson, H. E., Joy, R. M., Weir, M. E., ... & Ballif, B. A. (2017). Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2. Biochemical Journal, 474(23), 3963-3984.

Kikuta, K., Kubota, D., Yoshida, A., Qiao, Z., Morioka, H., Nakamura, M., ... & Kondo, T. (2017). Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1865(9), 1160-1166.

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For research use only. Not intended for any clinical use.

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