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  |  

Mouse Anti-DCP1B Recombinant Antibody (2D8) (CBMAB-D0388-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Decapping MRNA 1B (DCP1B). The antibody can be used for immunoassay techniques, such as WB.
See all DCP1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D8
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 167-473 of human DCP1B(NP_689853) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Decapping MRNA 1B
Introduction
DCP1B belongs to a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover.
Entrez Gene ID
196513
UniProt ID
Q8IZD4
Alternative Names
Decapping MRNA 1B; DCP1 Decapping Enzyme Homolog B (S. Cerevisiae); DCP1 Decapping Enzyme Homolog B; MRNA-Decapping Enzyme 1B; Decapping Enzyme HDcp1b; EC 3.-.-.-; DCP1;
Function
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
Exonucleolytic catabolism of deadenylated mRNA Source: Reactome
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Positive regulation of catalytic activity Source: InterPro
Cellular Location
Cytoplasm; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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