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Mouse Anti-DCTN6 Recombinant Antibody (A-2) (CBMAB-D0420-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynactin Subunit 6 (DCTN6). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DCTN6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A-2
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynactin Subunit 6
Introduction
DCTN6 contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known.
Entrez Gene ID
Human10671
Mouse22428
Rat290798
UniProt ID
HumanO00399
MouseQ9WUB4
RatD4ADD8
Alternative Names
Dynactin Subunit 6; Dynactin Subunit P27; Protein WS-3; Dynactin 6; WS3; Novel RGD-Containing Protein; WS-3; P27;
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Mitotic spindle organization Source: GO_Central
Cellular Location
Cytoskeleton; Kinetochore
PTM
Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.

Sharoar, M. G., Zhou, J., Benoit, M., He, W., & Yan, R. (2021). Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains. Neurobiology of Aging, 107, 21-29.

Fokin, A. I., David, V., Oguievetskaia, K., Derivery, E., Stone, C. E., Cao, L., ... & Gautreau, A. M. (2021). The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex. Science advances, 7(3), eabd5956.

Su, X., Li, H., Chen, S., & Qin, C. (2021). Study on the prognostic values of dynactin genes in low-grade glioma. Technology in Cancer Research & Treatment, 20, 15330338211010143.

Borca, M. V., Vuono, E. A., Ramirez-Medina, E., Azzinaro, P., Berggren, K. A., Singer, M., ... & Gladue, D. P. (2019). Structural glycoprotein E2 of classical swine fever virus interacts with host protein dynactin subunit 6 (DCTN6) during the virus infectious cycle. Journal of Virology, 94(1), e01642-19.

D’Aurora, M., Budani, M. C., Franchi, S., Sarra, A., Stuppia, L., Tiboni, G. M., & Gatta, V. (2019). Dynactin pathway-related gene expression is altered by aging, but not by vitrification. Reproductive Toxicology, 88, 48-55.

Wang, Q., Wang, X., Liang, Q., Wang, S., Liao, X., Li, D., & Pan, F. (2018). Prognostic value of dynactin mRNA expression in cutaneous melanoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 24, 3752.

Luo, S., Jing, L., Zhao, T., Li, Y., Liu, Z., & Diao, A. (2017). Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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