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Rabbit Anti-DCTPP1 Recombinant Antibody (074) (CBMAB-X0010-YC)

Provided herein is a Rabbit monoclonal antibody against Human DCTPP1. The antibody, clone 074, can be used for immunoassay techniques, such as ELISA.
See all DCTPP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
074
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant human XTP3TPA / DCTPP1 protein (Catalog#14577-H07E)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DCTP Pyrophosphatase 1
Introduction
DCTPP1 is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. DCTPP1 may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. DCTPP1 has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. DCTPP1 may protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
Entrez Gene ID
79077
UniProt ID
Q9H773
Alternative Names
CDA03; RS21C6; XTP3TPA
Function
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
Biological Process
dCTP catabolic process Source: UniProtKB
DNA protection Source: UniProtKB
Nucleoside triphosphate catabolic process Source: UniProtKB
Cellular Location
Cytosol; Nucleus; Mitochondrion

Niu, M., Shan, M., Liu, Y., Song, Y., Han, J. G., Sun, S., ... & Zhang, G. Q. (2021). DCTPP1, an oncogene regulated by miR-378a-3p, promotes proliferation of breast cancer via DNA repair signaling pathway. Frontiers in oncology, 11, 723.

Mamoor, S. (2021). Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

Martínez-Arribas, B., Requena, C. E., Pérez-Moreno, G., Ruíz-Pérez, L. M., Vidal, A. E., & González-Pacanowska, D. (2020). DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools. Cellular and Molecular Life Sciences, 77(8), 1645-1660.

Yue, Z., Shusheng, J., Hongtao, S., Shu, Z., Lan, H., Qingyuan, Z., ... & Yuanxi, H. (2020). Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT. Aging (Albany NY), 12(14), 14754.

Friese, A., Kapoor, S., Schneidewind, T., Vidadala, S. R., Sardana, J., Brause, A., ... & Waldmann, H. (2019). Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling. Angewandte Chemie, 131(37), 13143-13147.

Lu, J., Dong, W., He, H., Han, Z., Zhuo, Y., Mo, R., ... & Zhong, W. (2018). Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer. International journal of biological macromolecules, 118, 599-609.

Llona-Minguez, S., Hoglund, A., Wiita, E., Almlof, I., Mateus, A., Calderon-Montano, J. M., ... & Helleday, T. (2017). Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1. Journal of Medicinal Chemistry, 60(5), 2148-2154.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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