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Mouse Anti-DCUN1D3 Recombinant Antibody (F-7) (CBMAB-D0425-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Defective In Cullin Neddylation 1 Domain Containing 3 (DCUN1D3). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DCUN1D3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F-7
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Defective In Cullin Neddylation 1 Domain Containing 3
Introduction
DCUN1D3 (Defective In Cullin Neddylation 1 Domain Containing 3) is a protein coding gene. And a paralog is DCUN1D2.
Entrez Gene ID
Human123879
Mouse233805
Rat309035
UniProt ID
HumanQ8IWE4
MouseQ8K0V2
RatQ4V8B2
Alternative Names
Defective In Cullin Neddylation 1 Domain Containing 3; Defective In Cullin Neddylation Protein 1-Like Protein 3; Squamous Cell Carcinoma-Related Oncogene 3; DCUN1 Domain-Containing Protein 3; SCCRO3; DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S. Cerevisiae); DCN1, Defective In Cullin Neddylation 1, Domain Containing 3; DCN1-Like Protein 3; 44M2.4;
Function
Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379).

At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211).
Biological Process
Negative regulation of cell growth Source: UniProtKB
Negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of protein neddylation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of protein neddylation Source: UniProtKB
Positive regulation of ubiquitin-protein transferase activity Source: GO_Central
Post-translational protein modification Source: Reactome
Protein neddylation Source: GO_Central
Regulation of cell cycle process Source: UniProtKB
Regulation of protein neddylation Source: UniProtKB
Response to gamma radiation Source: UniProtKB
Response to UV-C Source: UniProtKB
Cellular Location
Nucleus; Cell membrane; Cytoplasm; Perinuclear region. After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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