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Mouse Anti-DCXR Recombinant Antibody (4D11) (CBMAB-D0436-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dicarbonyl And L-Xylulose Reductase (DCXR). The antibody can be used for immunoassay techniques, such as FC, IF, IHC-P, WB.
See all DCXR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D11
Antibody Isotype
IgG1
Application
FC, IF, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human DCXR (NP_057370) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dicarbonyl And L-Xylulose Reductase
Introduction
DCXR acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria.
Entrez Gene ID
51181
UniProt ID
Q7Z4W1
Alternative Names
Dicarbonyl And L-Xylulose Reductase; Dicarbonyl/L-Xylulose Reductase; Short Chain Dehydrogenase/Reductase Family 20C Member 1; Kidney Dicarbonyl Reductase; Sperm Surface Protein P34H; Carbonyl Reductase II; EC 1.1.1.10; SDR20C1; KIDCR; XR;
Function
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Biological Process
D-xylose metabolic process Source: UniProtKB-KW
Glucose metabolic process Source: UniProtKB
Glucuronate catabolic process to xylulose 5-phosphate Source: Reactome
NADP metabolic process Source: Ensembl
Positive regulation of reactive oxygen species metabolic process Source: UniProtKB
Xylulose metabolic process Source: UniProtKB
Cellular Location
Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
Involvement in disease
Pentosuria (PNTSU):
An inborn error of metabolism characterized by excessive urinary excretion of L-xylulose.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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