Rabbit Anti-DEPP1 Recombinant Antibody (CBXF-0066) (CBMAB-F1383-CQ)

This product is a rabbit antibody that recognizes DEPP1. The antibody CBXF-0066 can be used for immunoassay techniques such as: WB.
See all DEPP1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBXF-0066

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

DEPP1, Autophagy Regulator

Introduction

The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1.

Entrez Gene ID

11067

UniProt ID

Q9NTK1

Alternative Names

DEPP1, Autophagy Regulator; Decidual Protein Induced By Progesterone; C10orf10; Chromosome 10 Open Reading Frame 10; Fasting-Induced Gene Protein; Fasting Induced; DEPP; FIG;

Function

Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.

Biological Process

Autophagy Source: UniProtKB-KW
Regulation of autophagy Source: UniProtKB

Cellular Location

Cytoplasm; Mitochondrion; Peroxisome. May localize to aggresomes (PubMed:24530860).

References

Kuwahara, M., Akasaki, Y., Kurakazu, I., Sueishi, T., Toya, M., Uchida, T., ... & Nakashima, Y. (2022). C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis. The FASEB Journal, 36(2), e22145.

Li, W., Ji, M., Lin, Y., Miao, Y., Chen, S., & Li, H. (2018). DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS‐induced FGF21. The FASEB Journal, 32(10), 5459-5469.

Salcher, S., Hermann, M., Kiechl-Kohlendorfer, U., Ausserlechner, M. J., & Obexer, P. (2017). C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Molecular cancer, 16(1), 1-17.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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