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Rabbit Anti-DIRAS1 Recombinant Antibody (EG964) (CBMAB-EN1144-LY)

The product is antibody recognizes DIRA1. The antibody EG964 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all DIRAS1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG964
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human DIRA1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DIRAS Family GTPase 1
Entrez Gene ID
148252
UniProt ID
O95057
Function
Displays low GTPase activity and exists predominantly in the GTP-bound form.
Biological Process
Signal transduction Source: InterPro
Cellular Location
Cell membrane

Liu, H., Shu, W., Liu, T., Li, Q., & Gong, M. (2022). Analysis of the function and mechanism of DIRAS1 in osteosarcoma. Tissue and Cell, 101794.

Rothhammer-Hampl, T., Liesenberg, F., Hansen, N., Hoja, S., Delic, S., Reifenberger, G., & Riemenschneider, M. J. (2021). Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. Cancers, 13(20), 5113.

Kaplan, Ö., Pekmez, M., Akıncı, Y., Ataklı, H. D., Eren, F., Dirican, A. C., ... & Özkara, Ç. (2021). The relationship between DIRAS1 gene and idiopathic generalized epilepsy in the Turkish population. Gene Reports, 23, 101177.

Yang, B., Ma, H., & Bian, Y. (2021). LINC00261 Inhibits Esophageal Cancer Radioresistance by Down-Regulating microRNA-552-3p and Promoting DIRAS1. Cancer Management and Research, 13, 8559.

Li, X., Liu, S., Fang, X., He, C., & Hu, X. (2019). The mechanisms of DIRAS family members in role of tumor suppressor. Journal of cellular physiology, 234(5), 5564-5577.

Sutton, M. N., Yang, H., Huang, G. Y., Fu, C., Pontikos, M., Wang, Y., ... & Bast Jr, R. C. (2018). RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy, 14(4), 637-653.

Sutton, M. N. (2017). The Role of the DIRAS Family Members in Regulating Ras Function, Cancer Growth and Autophagy.

Wielaender, F., Sarviaho, R., James, F., Hytönen, M. K., Cortez, M. A., Kluger, G., ... & Lohi, H. (2017). Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1. Proceedings of the National Academy of Sciences, 114(10), 2669-2674.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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