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Mouse Anti-DKK3 Recombinant Antibody (4G7) (CBMAB-D0992-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DKK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
4G7
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dickkopf WNT Signaling Pathway Inhibitor 3
Introduction
DKK3 is a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Entrez Gene ID
Human27122
Monkey701549
UniProt ID
HumanQ9UBP4
MonkeyF6WNA0
Alternative Names
Dickkopf WNT Signaling Pathway Inhibitor 3; Regulated In Glioma; Dickkopf-3; HDkk-3; Dkk-3; REIC; Dickkopf (Xenopus Laevis) Homolog 3; Dickkopf 3 Homolog (Xenopus Laevis);
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Biological Process
Adrenal gland development Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Negative regulation of aldosterone biosynthetic process Source: UniProtKB
Negative regulation of anti-Mullerian hormone signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Negative regulation of cortisol biosynthetic process Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transforming growth factor beta receptor signaling pathway Source: ParkinsonsUK-UCL
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Secreted
PTM
N- and O-glycosylated.

Katase, N., Nagano, K., & Fujita, S. (2020). DKK3 expression and function in head and neck squamous cell carcinoma and other cancers. Journal of oral biosciences, 62(1), 9-15.

Zhou, C., Zhao, J., Liu, J., Wei, S., Xia, Y., Xia, W., ... & Huang, H. (2019). LncRNA SNHG16 promotes epithelial-mesenchymal transition via down-regulation of DKK3 in gastric cancer. Cancer Biomarkers, 26(4), 393-401.

Bhattacharyya, S., Feferman, L., & Tobacman, J. K. (2019). Dihydrotestosterone inhibits arylsulfatase B and Dickkopf Wnt signaling pathway inhibitor (DKK)‐3 leading to enhanced Wnt signaling in prostate epithelium in response to stromal Wnt3A. The Prostate, 79(7), 689-700.

Karamariti, E., Zhai, C., Yu, B., Qiao, L., Wang, Z., Potter, C. M., ... & Xu, Q. (2018). DKK3 (Dickkopf 3) alters atherosclerotic plaque phenotype involving vascular progenitor and fibroblast differentiation into smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology, 38(2), 425-437.

Hamzehzadeh, L., Caraglia, M., Atkin, S. L., & Sahebkar, A. (2018). Dickkopf homolog 3 (DKK3): A candidate for detection and treatment of cancers?. Journal of Cellular Physiology, 233(6), 4595-4605.

Bhattacharyya, S., Feferman, L., & Tobacman, J. K. (2017). Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3). Oncotarget, 8(59), 100242.

Zhou, S., Zhu, Y., Mashrah, M., Zhang, X., He, Z., Yao, Z., ... & Zhang, C. (2017). Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis. Oncology Reports, 37(2), 979-985.

Zhang, L., Sun, C., Jin, Y., Gao, K., Shi, X., Qiu, W., ... & Zhang, L. (2017). Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease, 60(2), 733-746.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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