Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-DKK3 Recombinant Antibody (D0995) (V2LY-0425-LY404)


See all DKK3 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
D0995
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant Human Dkk3 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dickkopf WNT Signaling Pathway Inhibitor 3
Entrez Gene ID
27122
UniProt ID
Q9UBP4
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Biological Process
Adrenal gland development Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Negative regulation of aldosterone biosynthetic process Source: UniProtKB
Negative regulation of anti-Mullerian hormone signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Negative regulation of cortisol biosynthetic process Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transforming growth factor beta receptor signaling pathway Source: ParkinsonsUK-UCL
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Secreted
PTM
N- and O-glycosylated.
More Infomation

Katase, N., Nagano, K., & Fujita, S. (2020). DKK3 expression and function in head and neck squamous cell carcinoma and other cancers. Journal of oral biosciences, 62(1), 9-15.

Zhou, C., Zhao, J., Liu, J., Wei, S., Xia, Y., Xia, W., ... & Huang, H. (2019). LncRNA SNHG16 promotes epithelial-mesenchymal transition via down-regulation of DKK3 in gastric cancer. Cancer Biomarkers, 26(4), 393-401.

Bhattacharyya, S., Feferman, L., & Tobacman, J. K. (2019). Dihydrotestosterone inhibits arylsulfatase B and Dickkopf Wnt signaling pathway inhibitor (DKK)‐3 leading to enhanced Wnt signaling in prostate epithelium in response to stromal Wnt3A. The Prostate, 79(7), 689-700.

Karamariti, E., Zhai, C., Yu, B., Qiao, L., Wang, Z., Potter, C. M., ... & Xu, Q. (2018). DKK3 (Dickkopf 3) alters atherosclerotic plaque phenotype involving vascular progenitor and fibroblast differentiation into smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology, 38(2), 425-437.

Hamzehzadeh, L., Caraglia, M., Atkin, S. L., & Sahebkar, A. (2018). Dickkopf homolog 3 (DKK3): A candidate for detection and treatment of cancers?. Journal of Cellular Physiology, 233(6), 4595-4605.

Bhattacharyya, S., Feferman, L., & Tobacman, J. K. (2017). Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3). Oncotarget, 8(59), 100242.

Zhou, S., Zhu, Y., Mashrah, M., Zhang, X., He, Z., Yao, Z., ... & Zhang, C. (2017). Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis. Oncology Reports, 37(2), 979-985.

Zhang, L., Sun, C., Jin, Y., Gao, K., Shi, X., Qiu, W., ... & Zhang, L. (2017). Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease, 60(2), 733-746.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DKK3 Recombinant Antibody (D0995)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry