Mouse Anti-DLGAP1 Recombinant Antibody (10F766) (CBMAB-D1052-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DLG Associated Protein 1 (DLGAP1). The antibody can be used for immunoassay techniques, such as IIHC-Fr, IP, WB.
See all DLGAP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

10F766

Antibody Isotype

IgG2b

Application

IIHC-Fr, IP, WB

Basic Information

Immunogen

Fusion protein a.a. 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95 associated/binding protein 1, accession number P97836)

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

discs, large (Drosophila) homolog-associated protein 1

Introduction

DLGAP1 (DLG Associated Protein 1) is a protein coding gene. Diseases associated with DLGAP1 include Retinitis Pigmentosa 55 and Obsessive-Compulsive Disorder. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. And a paralog is DLGAP2.

Entrez Gene ID

Human	9229
Mouse	224997
Rat	65040

UniProt ID

Human	O14490
Mouse	Q9D415
Rat	P97836

Alternative Names

DLG Associated Protein 1; Discs Large Homolog Associated Protein 1; Guanylate Kinase-Associated Protein; SAP90/PSD-95-Associated Protein 1; SAPAP1; DAP-1; DAP1; GKAP; Discs, Large (Drosophila) Homolog-Associated Protein 1;

Function

Part of the postsynaptic scaffold in neuronal cells.

Biological Process

Chemical synaptic transmission Source: ProtInc
Regulation of postsynaptic neurotransmitter receptor activity Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic density; Synapse

References

Takahashi, Y., Yamazaki, K., Kamatani, Y., Kubo, M., Matsuda, K., & Asai, S. (2021). A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. Scientific reports, 11(1), 1-11.

Lu, J., Xu, Y., Xie, W., Tang, Y., Zhang, H., Wang, B., ... & Zhang, W. (2021). Long noncoding RNA DLGAP1-AS2 facilitates Wnt1 transcription through physically interacting with Six3 and drives the malignancy of gastric cancer. Cell death discovery, 7(1), 1-12.

Zhang, J., Yang, J., Yang, N., Ma, J., Lu, D., Dong, Y., ... & Cang, M. (2020). Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis. Lipids in health and disease, 19(1), 1-10.

Fan, Z., Qian, Y., Lu, Q., Wang, Y., Chang, S., & Yang, L. (2018). DLGAP 1 and NMDA receptor‐associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder. Brain and behavior, 8(2), e00914.

Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., ... & Dulawa, S. C. (2018). Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. Scientific reports, 8(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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