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Mouse Anti-DNAH9 Recombinant Antibody (440.4) (CBMAB-D1246-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynein Axonemal Heavy Chain 9 (DNAH9). The antibody can be used for immunoassay techniques, such as WB, IP, ELISA, ICC, IF.
See all DNAH9 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Chicken
Clone
440.4
Antibody Isotype
IgG2a
Application
WB, IP, ELISA, ICC, IF

Basic Information

Specificity
Human, Rat, Chicken
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Axonemal Heavy Chain 9
Introduction
DNAH9 is the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.
Entrez Gene ID
Human1770
Chicken417314
Rat117251
UniProt ID
HumanQ9NYC9
RatF1LV07
Alternative Names
Dynein Axonemal Heavy Chain 9; Dynein, Axonemal, Heavy Polypeptide 9; Axonemal Beta Dynein Heavy Chain 9; Ciliary Dynein Heavy Chain 9; DNAH17L; Dynein, Axonemal, Heavy Polypeptide 17-Like; Dynein Heavy Chain 9, Axonemal; DNAH9 Variant Protein; EC 3.1.26.3;
Function
Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718).

Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Biological Process
Cell projection organization Source: UniProtKB-KW
Cilium movement Source: UniProtKB
Microtubule-based movement Source: GO_Central
Cellular Location
Cilium axoneme. Found in the distal portion of ciliary axoneme.
Involvement in disease
Ciliary dyskinesia, primary, 40 (CILD40):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Some patients exhibit randomization of left-right body asymmetry and situs inversus. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD40 inheritance is autosomal recessive.

Chen, W., Zhang, Y., Shen, L., Zhu, J., Cai, K., Lu, Z., ... & Zhou, X. (2022). Biallelic DNAH9 mutations are identified in Chinese patients with defective left–right patterning and cilia-related complex congenital heart disease. Human Genetics, 1-15.

Zhang, T., Yuan, H., Zhu, H., Ying, Y., Ding, J., Ding, H., ... & Zhong, Y. (2022). Fetal congenital heart disease caused by compound heterozygous mutations in the DNAH9 gene: a case report. Frontiers in Genetics, 2784.

Tang, D., Sha, Y., Gao, Y., Zhang, J., Cheng, H., Zhang, J., ... & Cao, Y. (2021). Novel variants in DNAH9 lead to nonsyndromic severe asthenozoospermia. Reproductive Biology and Endocrinology, 19(1), 1-9.

Tate, G. (2021). Whole-exome sequencing reveals a combination of extremely rare single-nucleotide polymorphism of DNAH9 and RSPH1 genes in a Japanese fetus with situs viscerum inversus. Medical Molecular Morphology, 54(3), 275-280.

Takeuchi, K., Xu, Y., Ogawa, S., Ikejiri, M., Nakatani, K., Gotoh, S., ... & Fujisawa, T. (2021). A pediatric case of productive cough caused by novel variants in DNAH9. Human Genome Variation, 8(1), 1-3.

Omran, H., Hoeben, I. M., Noethe-Menchen, T., Jelten, L., Frank, D., Werner, C., ... & Loges, N. T. (2019). Recessive DNAH9 Loss-of-Function Mutations Cause Absence of ODAs Type 2 and Only Subtle Respiratory Ciliary Beating Defects. In C25. CLINICAL AND TRANSLATIONAL STUDIES IN RARE LUNG DISEASE (pp. A7385-A7385). American Thoracic Society.

Fassad, M. R., Shoemark, A., Legendre, M., Hirst, R. A., Koll, F., le Borgne, P., ... & Mitchison, H. M. (2018). Mutations in outer dynein arm heavy chain DNAH9 cause motile cilia defects and situs inversus. The American Journal of Human Genetics, 103(6), 984-994.

Loges, N. T., Antony, D., Maver, A., Deardorff, M. A., Güleç, E. Y., Gezdirici, A., ... & Schmidts, M. (2018). Recessive DNAH9 loss-of-function mutations cause laterality defects and subtle respiratory ciliary-beating defects. The American Journal of Human Genetics, 103(6), 995-1008.

Shoemark, A., Fassad, M. R., Daudvohra, F., Burgoyne, T., Hirst, R. A., Hayes, J., ... & Mitchison, H. (2018). Motile cilia structure and function in patients with mutations in the outer dynein arm heavy chain DNAH9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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