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Mouse Anti-DNAJC10 Recombinant Antibody (3A8) (CBMAB-D1305-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member C10 (DNAJC10). The antibody can be used for immunoassay techniques, such as WB.
See all DNAJC10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A8
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
DNAJC10 (NP_061854, 688 a.a. ~ 794 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DnaJ (Hsp40) homolog, subfamily C, member 10
Introduction
DNAJC10 is an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins.
Entrez Gene ID
54431
UniProt ID
Q8IXB1
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member C10; Endoplasmic Reticulum DNA J Domain-Containing Protein 5; Protein Disulfide Isomerase Family A, Member 19; DnaJ (Hsp40) Homolog, Subfamily C, Member 10; ER-Resident Protein ERdj5; Macrothioredoxin; ERdj5;
Function
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Biological Process
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Positive regulation of ATPase activity Source: UniProtKB
Protein folding in endoplasmic reticulum Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Cellular Location
Endoplasmic reticulum lumen
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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