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Rat Anti-DNAL1 Recombinant Antibody (6D362) (CBMAB-D1328-YC)

Provided herein is a Rat monoclonal antibody, which binds to Dynein Axonemal Light Chain 1 (DNAL1). The antibody can be used for immunoassay techniques, such as FC, WB.
See all DNAL1 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
6D362
Antibody Isotype
IgM
Application
FC, WB

Basic Information

Immunogen
Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN)
Specificity
Human, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Axonemal Light Chain 1
Introduction
DNAL1 is an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella.
Entrez Gene ID
Human83544
Mouse105000
UniProt ID
HumanQ4LDG9
MouseQ05A62
Alternative Names
Dynein Axonemal Light Chain 1; C14orf168; LC1; Chromosome 14 Open Reading Frame 168; Dynein Light Chain 1, Axonemal; CILD16;
Function
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity).

Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).

Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787).
Biological Process
Outer dynein arm assembly Source: UniProtKB
Cellular Location
Cilium axoneme
Involvement in disease
Ciliary dyskinesia, primary, 16 (CILD16):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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