Rabbit Anti-DNM3 Monoclonal Antibody (EPR9055) (CBMAB-1090-YC)

Provided herein is a rabbit monoclonal antibody against Human DNM3. The antibody, clone EPR9055, can be used for immunoassay techniques, such as WB.
See all DNM3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EPR9055

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Synthetic peptide corresponding to amino acid residues in Human Dynamin 3.

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Dynamin 3

Introduction

Dynamin 3 is a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. Dynamin 3 functions in the development of megakaryocytes.

Entrez Gene ID

Human	26052
Mouse	103967

UniProt ID

Human	Q9UQ16
Mouse	Q8BZ98

Alternative Names

Dyna III

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

Biological Process

Dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
Endocytosis Source: UniProtKB
Filopodium assembly Source: UniProtKB
Membrane fusion Source: GO_Central
Mitochondrial fission Source: GO_Central
Negative regulation of dendritic spine morphogenesis Source: Ensembl
Positive regulation of filopodium assembly Source: Ensembl
Positive regulation of synaptic vesicle recycling Source: Ensembl
Postsynaptic neurotransmitter receptor internalization Source: GO_Central
Receptor internalization Source: GO_Central
Regulation of synapse structure or activity Source: GO_Central
Synapse assembly Source: UniProtKB
Synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central

Cellular Location

Cytoplasm; Cytoskeleton. Microtubule-associated.

References

Fa, J. (2021). Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells. Oncology Letters, 22(1), 1-8.

Lu, Q., Ni, Y., Wang, W., Wang, L., Jiang, T., & Shang, L. (2021). Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET–GBR2–STAT3 Complex Formation. Frontiers in Cell and Developmental Biology, 9.

Yang, Z. H., Li, Y. S., Shi, M. M., Yang, J., Liu, Y. T., Mao, C. Y., ... & Xu, Y. M. (2019). SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson’s disease in Chinese population. Journal of Neurology, 266(7), 1796-1800.

Ma, Y., Guan, L., Han, Y., Zhou, Y., Li, X., Liu, Y., ... & Lu, W. (2019). siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway. Cancer Management and Research, 11, 5799.

Fernández‐Santiago, R., Garrido, A., Infante, J., González‐Aramburu, I., Sierra, M., Fernández, M., ... & Barcelona LRRK2 Study Group†. (2018). α‐synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine‐rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain. Movement Disorders, 33(4), 637-641.

Gu, C., Yao, J., & Sun, P. (2017). Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production. Oncology letters, 13(6), 4776-4784.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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