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Mouse Anti-DOK2 Recombinant Antibody (G-3) (CBMAB-D1504-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Docking Protein 2 (DOK2). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DOK2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
G-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Docking Protein 2
Introduction
DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Entrez Gene ID
Mouse13449
Rat290361
UniProt ID
MouseO70469
RatD3ZHJ4
Alternative Names
Docking Protein 2; Downstream Of Tyrosine Kinase 2; Docking Protein 2, 56kDa; Docking Protein 2, 56kD; P56(Dok-2); P56dok-2; P56DOK;
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Ras protein signal transduction Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cytosol
PTM
On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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