Rabbit Anti-DOK4 Recombinant Antibody (EG989) (CBMAB-EN1171-LY)

The product is antibody recognizes DOK4. The antibody EG989 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all DOK4 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG989

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human DOK4.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Docking Protein 4

Introduction

DOK4 (Docking Protein 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK6.

Entrez Gene ID

Human	55715
Mouse	114255

UniProt ID

Human	Q8TEW6
Mouse	Q99KE3

Alternative Names

Docking Protein 4; Downstream Of Tyrosine Kinase 4; Insulin Receptor Substrate 5; IRS-5; IRS5;

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity).

Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Biological Process

Nervous system development Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

Cellular Location

Cytosol

PTM

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.

References

Heidarizadi, A., Salimi, M., & Mozdarani, H. (2020). Study of DOK4 gene expression and promoter methylation in sporadic breast cancer. Neoplasma, 67(4), 916-921.

Hooker, E., Baldwin, C., Roodman, V., Batra, A., Isa, N. N., Takano, T., & Lemay, S. (2017). Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4. Biochemical Journal, 474(9), 1509-1528.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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