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Rabbit Anti-DOK5 Recombinant Antibody (EG990) (CBMAB-EN1172-LY)

The product is antibody recognizes DOK5. The antibody EG990 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all DOK5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG990
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DOK5.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Docking Protein 5
Introduction
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Entrez Gene ID
Human55816
Mouse76829
UniProt ID
HumanQ9P104
MouseQ91ZM9
Alternative Names
Docking Protein 5; Downstream Of Tyrosine Kinase 5; Insulin Receptor Substrate 6; C20orf180; IRS-6; IRS6; Chromosome 20 Open Reading Frame 180;
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Cellular Location
Cytosol
PTM
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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