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Rat Anti-DPN Monoclonal Antibody (11D1CH11) (CBMAB-1005-YC)

Provided herein is a rat monoclonal antibody against Drosophila DPN. The antibody, clone 11D1CH11, can be used for immunoassay techniques, such as IHC, ICC and IF.
See all DPN antibodies
Published Data
Fig.1 Imp depletion prematurely ended MB neurogenesis. Representative confocal images of 48 h APF fly brains immunostained for GFP (green), Dpn (magenta) and Pros (blue) in control.
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Summary

Host Animal
Rat
Specificity
Common fruit fly
Clone
11D1CH11
Antibody Isotype
IgG2b, κ
Application
IHC, ICC, IF

Basic Information

Immunogen
Recombinant full length protein corresponding to Fruit fly (Drosophila melanogaster) Deadpan aa 1-435.
Specificity
Common fruit fly
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Deadpan
Introduction
Deadpan is one of the pan-neural genes, which encodes a helix-loop-helix protein closely related to the product of the segmentation gene hairy. The function of deadpan is essential for viability and is likely to be involved in the functional rather than the morphological differentiation of neurons.
Entrez Gene ID
35800
UniProt ID
Q26263
Alternative Names
CG8704-PA; anon-fast-evolving-1B12; dpn-PA
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:1427077, PubMed:28899667, PubMed:24618901).

In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH (PubMed:28899667, PubMed:23056424, PubMed:21262215, PubMed:24618901, PubMed:22357926).

As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch (PubMed:21262215, PubMed:22357926, PubMed:23056424).

In the developing larval and pupal brain, required for mushroom body differentiation (PubMed:22357926).

Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho (PubMed:8001118, PubMed:7651341).
Biological Process
Adult locomotory behavior Source: FlyBase
Anterior/posterior pattern specification Source: GO_Central
Dosage compensation Source: FlyBase
Larval locomotory behavior Source: FlyBase
Negative regulation of gene expression Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: FlyBase
Neuroblast development Source: UniProtKB
Positive regulation of mitotic nuclear division Source: FlyBase
Positive regulation of neuroblast proliferation Source: UniProtKB
R7 cell fate commitment Source: FlyBase
Regulation of neuroblast proliferation Source: UniProtKB
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Sex determination, establishment of X:A ratio Source: FlyBase
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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