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Mouse Anti-DPP3 Recombinant Antibody (3C6) (CBMAB-A2348-LY)

The product is antibody recognizes DPP3. The antibody 3C6 immunoassay techniques such as: WB, ELISA.
See all DPP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
DPP3 (AAH01446, 1 a.a. ~ 737 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dipeptidyl-peptidase 3
Introduction
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized. [provided by RefSeq]
Entrez Gene ID
10072
UniProt ID
Q9NY33
Alternative Names
DPPIII; FLJ11387; FLJ22331
Function
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063).

Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).
Biological Process
Proteolysis Source: UniProtKB
Cellular Location
Cytosol

Malovan, G., Hierzberger, B., Suraci, S., Schaefer, M., Santos, K., Jha, S., & Macheroux, P. (2022). The emerging role of dipeptidyl peptidase 3 in pathophysiology. The FEBS Journal.

Podversnik, H., Jha, S., Macheroux, P., & Breinbauer, R. (2022). Design and synthesis of efficient fluororethylene-peptidomimetic inhibitors of dipeptidyl peptidase III (DPP3). Bioorganic & Medicinal Chemistry, 116831.

Van Lier, D., Kox, M., & Pickkers, P. (2021). Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3. Journal of Internal Medicine, 289(6), 792-806.

Blet, A., Deniau, B., Santos, K., van Lier, D., Azibani, F., Wittebole, X., ... & Mebazaa, A. (2021). Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study. Critical Care, 25(1), 1-10.

Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., ... & Voors, A. A. (2021). Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure. European journal of heart failure, 23(6), 947-953.

Picod, A., Deniau, B., Vaittinada Ayar, P., Genest, M., Julian, N., Azibani, F., & Mebazaa, A. (2021). Alteration of the Renin–Angiotensin–Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3. American Journal of Respiratory and Critical Care Medicine, 203(4), 526-527.

Ren, X., Yu, J., Guo, L., & Ma, H. (2021). Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling. International Immunopharmacology, 96, 107595.

Jha, S., Taschler, U., Domenig, O., Poglitsch, M., Bourgeois, B., Pollheimer, M., ... & Macheroux, P. (2020). Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice. Journal of Biological Chemistry, 295(40), 13711-13723.

Rehfeld, L., Funk, E., Jha, S., Macheroux, P., Melander, O., & Bergmann, A. (2019). Novel methods for the quantification of dipeptidyl peptidase 3 (DPP3) concentration and activity in human blood samples. The Journal of Applied Laboratory Medicine, 3(6), 943-953.

Menale, C., Robinson, L. J., Palagano, E., Rigoni, R., Erreni, M., Almarza, A. J., ... & Sobacchi, C. (2019). Absence of dipeptidyl peptidase 3 increases oxidative stress and causes bone loss. Journal of Bone and Mineral Research, 34(11), 2133-2148.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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