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Mouse Anti-DRAM2 Recombinant Antibody (A3) (CBMAB-AP1947LY)


See all DRAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A3
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide HGLTLYDTAP.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DNA Damage Regulated Autophagy Modulator 2
Introduction
The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
Entrez Gene ID
128338
UniProt ID
Q6UX65
Alternative Names
DNA Damage Regulated Autophagy Modulator 2; Transmembrane Protein 77; TMEM77; DNA Damage-Regulated Autophagy Modulator Protein 2; DNA-Damage Regulated Autophagy Modulator 2; Damage Regulated Autophagy Modulator 2; WWFQ154; CORD21; PRO180;
Function
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Biological Process
Apoptotic process Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Photoreceptor cell maintenance Source: UniProtKB
Regulation of autophagy Source: UniProtKB
Visual perception Source: UniProtKB
Cellular Location
Lysosome membrane; Apical cell membrane; Photoreceptor inner segment. Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells.
Involvement in disease
Cone-rod dystrophy 21 (CORD21):
A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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