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Mouse Anti-DSE Recombinant Antibody (2C9F7) (CBMAB-D1740-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dermatan Sulfate Epimerase (DSE). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DSE antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2C9F7
Antibody Isotype
IgM
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dermatan Sulfate Epimerase
Introduction
DSE is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18.
Entrez Gene ID
Human29940
Mouse212898
UniProt ID
HumanQ9UL01
MouseQ8BLI4
Alternative Names
Dermatan Sulfate Epimerase; Squamous Cell Carcinoma Antigen Recognized By T-Cells 2; Chondroitin-Glucuronate 5-Epimerase; DS Epimerase; SART-2; SART2; Squamous Cell Carcinoma Antigen Recognized By T Cells 2;
Research Area
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Biological Process
Chondroitin sulfate biosynthetic process Source: UniProtKB-UniPathway
Chondroitin sulfate metabolic process Source: GO_Central
Dermatan sulfate biosynthetic process Source: UniProtKB
Dermatan sulfate metabolic process Source: GO_Central
Heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus membrane; Endoplasmic reticulum membrane; Microsome membrane; Cytoplasmic vesicle membrane
Involvement in disease
Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2):
A form of Ehlers-Danlos syndrome characterized by progressive multisystem manifestations, including joint dislocations and deformities, skin hyperextensibility, skin bruisability and fragility with recurrent large subcutaneous hematomas, cardiac valvular, respiratory, gastrointestinal, and ophthalmologic complications. Motor developmental delay is associated with muscle hypoplasia, muscle weakness, and an abnormal muscle fiber pattern in histology in adulthood.
Topology
Lumenal: 23-902
Helical: 903-923
Cytoplasmic: 924-933
Helical: 934-954
Lumenal: 955-958
PTM
N-glycosylated (PubMed:19004833, Ref. 7). Glycosylation is important for enzymatic activity (PubMed:19004833).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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