Mouse Anti-DSN1 Recombinant Antibody (2A7) (CBMAB-D1793-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DSN1 Homolog, MIS12 Kinetochore Complex Component (DSN1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DSN1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2A7

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

C20orf172 (NP_079194.2, 257 a.a. ~ 355 a.a) partial recombinant protein with GST tag. The immunogen sequence: MTYLGSSQNE VLNTKPDYQK ILQNQSKVFD CMELVMDELQ GSVKQLQAFM DESTQCFQKV SVQLGKRSMQ QLDPSPARKL LKLQLQNPPA IHGSGSGSC

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 257-355

Target

Full Name

DSN1 Homolog, MIS12 Kinetochore Complex Component

Introduction

DSN1 is a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle.

Entrez Gene ID

79980

UniProt ID

Q9H410

Alternative Names

DSN1 Homolog, MIS12 Kinetochore Complex Component; C20orf172; MIS13; DSN1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae); DSN1, MIND Kinetochore Complex Component, Homolog; Kinetochore-Associated Protein DSN1 Homolog; DSN1, MIS12 Kinetochore Complex Component;

Research Area

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Biological Process

Cell division Source: UniProtKB-KW
Mitotic sister chromatid segregation Source: GO_Central

Cellular Location

Nucleus; Kinetochore. Associated with the kinetochore.

References

Wang, X., Lu, X., Wang, P., Chen, Q., Xiong, L., Tang, M., ... & Lin, J. (2022). SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. Journal of translational medicine, 20(1), 1-18.

Li, F. N., Zhang, Q. Y., Li, O., Liu, S. L., Yang, Z. Y., Pan, L. J., ... & Dong, P. (2021). ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1. International journal of biological sciences, 17(8), 1909.

Peng, Q., Wen, T., Liu, D., Wang, S., Jiang, X., Zhao, S., & Huang, G. (2021). DSN1 is a prognostic biomarker and correlated with clinical characterize in breast cancer. International Immunopharmacology, 101, 107605.

Li, Q., Liang, J., & Chen, B. (2020). Identification of CDCA8, DSN1 and BIRC5 in regulating cell cycle and apoptosis in osteosarcoma using bioinformatics and cell biology. Technology in Cancer Research & Treatment, 19, 1533033820965605.

Sun, C., Huang, S., Ju, W., Hou, Y., Wang, Z., Liu, Y., ... & He, X. (2018). Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma. Human pathology, 81, 113-120.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DSN1 Recombinant Antibody (2A7)

Related Products

Recombinant Mouse Anti-DSN1 Recombinant Antibody (RD36-1)

Mouse Anti-DSN1 Recombinant Antibody (2A7)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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