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Mouse Anti-DTX1 Recombinant Antibody (CBMY-C0185) (CBMAB-V208-C0188-YY)

This product is mouse antibody that recognizes DTX1. The antibody CBMY-C0185 can be used for immunoassay techniques such as: ELISA, IP
See all DTX1 antibodies

Summary

Host Animal
Mouse
Specificity
C. diphtheriae
Clone
CBMY-C0185
Antibody Isotype
IgG1
Application
ELISA, IP

Basic Information

Specificity
C. diphtheriae
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
E3 ubiquitin-protein ligase DTX1
Introduction
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
Research Area
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to leukemia inhibitory factor Source: Ensembl
Glial cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: UniProtKB
Negative regulation of T cell differentiation Source: Ensembl
Notch signaling pathway Source: GO_Central
Protein ubiquitination Source: GO_Central
Regulation of Notch signaling pathway Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
PTM
Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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