Mouse Anti-ECI2 Recombinant Antibody (1C8) (CBMAB-P0289-YC)

Provided herein is a Mouse monoclonal antibody against Human Enoyl-CoA delta isomerase 2. The antibody can be used for immunoassay techniques, such as WB, IHC, IF.
See all ECI2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Dog, Rat, Monkey, Mouse

Clone

1C8

Antibody Isotype

IgG2b

Application

WB, IHC, IF

Basic Information

Immunogen

Full length human recombinant protein of human PECI(NP_006108) produced in HEK293T cell

Specificity

Human, Dog, Rat, Monkey, Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Enoyl-CoA delta isomerase 2

Introduction

ECI2 is a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates.

Entrez Gene ID

Human	10455
Mouse	23986
Rat	291075
Monkey	709579
Dog	478706

UniProt ID

Human	O75521
Mouse	Q9WUR2
Rat	Q5XIC0
Monkey	F7AWB0
Dog	F1PMM1

Alternative Names

ACBD2; DRS-1; DRS1; HCA88; PECI; dJ1013A10.3

Research Area

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.

Biological Process

Fatty acid beta-oxidation Source: UniProtKB
Fatty acid catabolic process Source: UniProtKB

Cellular Location

Isoform 1: Mitochondrion
Isoform 2: Peroxisome matrix

References

Dundr, P., Bártů, M., Hojný, J., Michálková, R., Hájková, N., Stružinská, I., ... & Franková, V. (2020). HNF1B, EZH2 and ECI2 in prostate carcinoma. Molecular, immunohistochemical and clinico-pathological study. Scientific reports, 10(1), 1-17.

Yen, M. Y., Chu, H. T., Chen, Y. C., & Tsai, J. J. (2018, October). Quantitative Analysis of ECI2 Expression from RNA-Seq for Breast Cancer Gene Signatures. In 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) (pp. 251-254). IEEE.

Hwang, J. H., An, S. M., Park, D. H., Kang, D. G., Kim, T. W., Park, H. C., ... & Kim, C. W. (2018). The identification of non-synonymous SNP in the Enoyl-CoA delta isomerase 2 (ECI2) gene and its Association with Meat Quality Traits in Berkshire pigs. The Journal of the Korean Society of International Agriculture.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ECI2 Recombinant Antibody (1H4)

Mouse Anti-ECI2 Recombinant Antibody (CBFYE-0409)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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