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Mouse Anti-EDNRA Recombinant Antibody (2A5) (CBMAB-A2456-LY)

The product is antibody recognizes EDNRA. The antibody 2A5 immunoassay techniques such as: WB, ELISA.
See all EDNRA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EDNRA (AAH22511, 18 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
endothelin receptor type A
Entrez Gene ID
1909
UniProt ID
P25101
Alternative Names
ETA; ETRA
Research Area
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1> ET2>> ET3.
Biological Process
Activation of adenylate cyclase activity Source: ProtInc
Activation of phospholipase C activity Source: ProtInc
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
Artery smooth muscle contraction Source: BHF-UCL
Branching involved in blood vessel morphogenesis Source: Ensembl
Cell population proliferation Source: ProtInc
Enteric nervous system development Source: InterPro
G protein-coupled receptor signaling pathway Source: UniProtKB
Head development Source: Ensembl
Heart development Source: Ensembl
In utero embryonic development Source: Ensembl
Neural crest cell development Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Regulation of blood pressure Source: InterPro
Regulation of glucose transmembrane transport Source: Ensembl
Respiratory gaseous exchange by respiratory system Source: UniProtKB
Response to hypoxia Source: Ensembl
Signal transduction Source: ProtInc
Smooth muscle contraction Source: ProtInc
Vasoconstriction Source: BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Mandibulofacial dysostosis with alopecia (MFDA):
A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility.
Topology
Extracellular: 21-80
Helical: 81-102
Cytoplasmic: 103-112
Helical: 113-132
Extracellular: 133-159
Helical: 160-181
Cytoplasmic: 182-205
Helical: 206-229
Extracellular: 230-256
Helical: 257-278
Cytoplasmic: 279-306
Helical: 307-328
Extracellular: 329-347
Helical: 348-372
Cytoplasmic: 373-427

Pan, Z., Chen, Q., Ding, H., & Li, H. (2022). MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA. Journal of Thrombosis and Thrombolysis, 1-9.

Zhou, W., Xi, D., Shi, Y., Wang, L., Zhong, H., Huang, Z., ... & He, F. (2021). MicroRNA‑1929‑3p participates in murine cytomegalovirus‑induced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation Corrigendum in/10.3892/ijmm. 2022.5082. international journal of molecular medicine, 47(2), 719-731.

Wang, Y., Huang, Z., Zhong, H., Wang, L., Xi, D., Shi, Y., ... & He, F. (2020). Mir-1929-3p overexpression alleviates murine cytomegalovirus-induced hypertensive myocardial remodeling by suppressing ednra/nlrp3 inflammasome activation. BioMed Research International, 2020.

Zeng, Y., Chen, R., Ma, M., Liu, B., Xia, J., Xu, H., ... & Zhang, L. (2019). Associations of EDNRA and EDNRB polymorphisms with intracerebral hemorrhage. World Neurosurgery, 129, e472-e477.

Minchenko, D. O., Tsymbal, D. O., Riabovol, O. O., Viletska, Y. M., Lahanovska, Y. O., Sliusar, M. Y., ... & Minchenko, O. H. (2019). Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells. Endocrine regulations, 53(4), 250-262.

Liu, H., Luo, Q., Zhang, J., Mo, C., Wang, Y., & Li, J. (2019). Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution. General and comparative endocrinology, 283, 113231.

Wei, W., Shi, L., Chen, W., Hu, L., Chen, D., Shi, X., ... & Wu, Z. (2018). miR-200c regulates the proliferation, apoptosis and invasion of gastric carcinoma cells through the downregulation of EDNRA expression. International journal of molecular medicine, 41(3), 1619-1626.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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