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Mouse Anti-EIF1 Recombinant Antibody (CBFYE-0632) (V2LY-0425-LY1625)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-0632
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Immunogen
Full lengthhuman EIF1 protein produced in HEK293T cells.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IF(ICC)1-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 1
Entrez Gene ID
Human10209
Mouse20918
Rat287703
UniProt ID
HumanP41567
MouseP48024
RatB0K008
Research Area
Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.
Biological Process
Regulation of translational initiation Source: CACAO
Cellular Location
Nucleus; Cytoplasm; Eukaryotic 43S preinitiation complex
More Infomation

Golob-Schwarzl, N., Puchas, P., Gogg-Kamerer, M., Weichert, W., Göppert, B., & Haybaeck, J. (2020). New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal adenocarcinoma. Anticancer Research, 40(6), 3109-3118.

Sehrawat, U., Koning, F., Ashkenazi, S., Stelzer, G., Leshkowitz, D., & Dikstein, R. (2019). Cancer-associated eukaryotic translation initiation factor 1A mutants impair Rps3 and Rps10 binding and enhance scanning of cell cycle genes. Molecular and Cellular Biology, 39(3), e00441-18.

Thakur, A., & Hinnebusch, A. G. (2018). eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex. Proceedings of the National Academy of Sciences, 115(18), E4159-E4168.

Haimov, O., Sehrawat, U., Tamarkin-Ben Harush, A., Bahat, A., Uzonyi, A., Will, A., ... & Dikstein, R. (2018). Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and-independent translation. Molecular and cellular biology, 38(18), e00139-18.

Gogoi, P., & Kanaujia, S. P. (2018). Archaeal and eukaryal translation initiation factor 1 differ in their RNA interacting loops. FEBS letters, 592(9), 1602-1610.

Llácer, J. L., Hussain, T., Saini, A. K., Nanda, J. S., Kaur, S., Gordiyenko, Y., ... & Ramakrishnan, V. (2018). Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife, 7, e39273.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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