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Rabbit Anti-EIF1 (N-terminus) Recombinant Antibody (CBFYE-0633) (CBMAB-E1039-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Dog
Clone
CBFYE-0633
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the N-terminal domain of human eIF1. Species Sequence Homology: canine
Specificity
Human, Mouse, Rat, Monkey, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM Sodium HEPES, pH 7.5, 150mM sodium chloride, 100 ug/ml BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Eukaryotic Translation Initiation Factor 1
Introduction
EIF1 (Eukaryotic Translation Initiation Factor 1) is a Protein Coding gene. Among its related pathways are Translation Factors and RNA transport. Gene Ontology (GO) annotations related to this gene include translation factor activity, RNA binding. An important paralog of this gene is EIF1B.
Entrez Gene ID
Human10209
Mouse20918
Rat287703
Monkey704606
Dog403674
UniProt ID
HumanP41567
MouseP48024
RatB0K008
DogJ9PA62
Alternative Names
Eukaryotic Translation Initiation Factor 1; Protein Translation Factor SUI1 Homolog; Sui1iso1; A121; SUI1; EIF-1; EIF1A; ISO1; EIF1
Research Area
Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.
Biological Process
Regulation of translational initiation Source: CACAO
Cellular Location
Nucleus; Cytoplasm; Eukaryotic 43S preinitiation complex
More Infomation

Golob-Schwarzl, N., Puchas, P., Gogg-Kamerer, M., Weichert, W., Göppert, B., & Haybaeck, J. (2020). New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal adenocarcinoma. Anticancer Research, 40(6), 3109-3118.

Sehrawat, U., Koning, F., Ashkenazi, S., Stelzer, G., Leshkowitz, D., & Dikstein, R. (2019). Cancer-associated eukaryotic translation initiation factor 1A mutants impair Rps3 and Rps10 binding and enhance scanning of cell cycle genes. Molecular and Cellular Biology, 39(3), e00441-18.

Thakur, A., & Hinnebusch, A. G. (2018). eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex. Proceedings of the National Academy of Sciences, 115(18), E4159-E4168.

Haimov, O., Sehrawat, U., Tamarkin-Ben Harush, A., Bahat, A., Uzonyi, A., Will, A., ... & Dikstein, R. (2018). Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and-independent translation. Molecular and cellular biology, 38(18), e00139-18.

Gogoi, P., & Kanaujia, S. P. (2018). Archaeal and eukaryal translation initiation factor 1 differ in their RNA interacting loops. FEBS letters, 592(9), 1602-1610.

Llácer, J. L., Hussain, T., Saini, A. K., Nanda, J. S., Kaur, S., Gordiyenko, Y., ... & Ramakrishnan, V. (2018). Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife, 7, e39273.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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