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Mouse Anti-EIF3G Recombinant Antibody (CBFYE-0680) (CBMAB-E1101-FY)

This product is mouse antibody that recognizes EIF3G. The antibody CBFYE-0680 can be used for immunoassay techniques such as: WB.
See all EIF3G antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0680
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 3 Subunit G
Introduction
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy.
Entrez Gene ID
8666
UniProt ID
O75821
Alternative Names
Eukaryotic Translation Initiation Factor 3 Subunit G; Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa; Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit; EIF3S4; Eukaryotic Translation Initiation Factor 3 Subunit P42; Eukaryotic Translation Initiation Factor 3, Subunit G; Eukaryotic Translation Initiation Factor 3 Subunit 4; EIF-3 RNA-Binding Subunit
Research Area
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).

The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).

The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

This subunit can bind 18S rRNA.

(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Biological Process
Formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Translational initiation Source: UniProtKB
Viral translational termination-reinitiation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Perinuclear region. Colocalizes with AIFM1 in the nucleus and perinuclear region.
PTM
Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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