Mouse Anti-EIF4EBP3 Recombinant Antibody (CBFYE-0728) (V2LY-0425-LY1756)

Name: Mouse Anti-EIF4EBP3 Recombinant Antibody (CBFYE-0728)
SKU: V2LY-0425-LY1756
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0728

Antibody Isotype

IgG2a, κ

Application

ELISA, IF, WB

Basic Information

Immunogen

Full-length recombinant EIF4EBP3.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Eukaryotic Translation Initiation Factor 4E Binding Protein 3

Entrez Gene ID

8637

UniProt ID

O60516

Research Area

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.

Biological Process

Negative regulation of translational initiation Source: GO_Central

Cellular Location

Cytoplasm; Eukaryotic translation initiation factor 4F complex; Membrane

PTM

Phosphorylated.

More Infomation

References

Zhai, S., Lin, S., Lin, Z., Xu, J., Ji, T., Chen, K., ... & Cai, X. (2020). eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. Gastric cancer, 23(3), 483-496.

Lv, K. T., Liu, Z., Feng, J., Zhao, W., Hao, T., Ding, W. Y., ... & Gao, L. J. (2018). MiR-22-3p regulates cell proliferation and inhibits cell apoptosis through targeting the eIF4EBP3 gene in human cervical squamous carcinoma cells. International journal of medical sciences, 15(2), 142.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-EIF4EBP3 (AA 1-100) Recombinant Antibody (CBFYE-0728)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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