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Mouse Anti-EIF4EBP3 (AA 1-100) Recombinant Antibody (CBFYE-0728) (CBMAB-E1160-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0728
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
EIF4EBP3 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
Eukaryotic Translation Initiation Factor 4E Binding Protein 3
Introduction
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.
Entrez Gene ID
8637
UniProt ID
O60516
Alternative Names
Eukaryotic Translation Initiation Factor 4E Binding Protein 3; EIF4E-Binding Protein 3; 4E-BP3; Eukaryotic Translation Initiation Factor 4E-Binding Protein 3; Eukaryotic Initiation Factor 4E-Binding Protein 3; 4EBP3
Research Area
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Biological Process
Negative regulation of translational initiation Source: GO_Central
Cellular Location
Cytoplasm; Eukaryotic translation initiation factor 4F complex; Membrane
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

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