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Mouse Anti-ELOVL3 Recombinant Antibody (CBFYE-0167) (CBMAB-E0395-FY)

This product is mouse antibody that recognizes ELOVL3. The antibody CBFYE-0167 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all ELOVL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0167
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide-QPYNFELSK
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELOVL Fatty Acid Elongase 3
Introduction
This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides.
Entrez Gene ID
83401
UniProt ID
Q9HB03
Alternative Names
ELOVL Fatty Acid Elongase 3; Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 3; Very Long Chain 3-Ketoacyl-CoA Synthase 3; Very Long Chain 3-Oxoacyl-CoA Synthase 3; Cold-Inducible Glycoprotein Of 30 KDa; 3-Keto Acyl-CoA Synthase ELOVL3
Research Area
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Biological Process
Alpha-linolenic acid metabolic process Source: Reactome
Fatty acid elongation, monounsaturated fatty acid Source: UniProtKB
Fatty acid elongation, polyunsaturated fatty acid Source: UniProtKB
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Linoleic acid metabolic process Source: Reactome
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
PTM
N-Glycosylated.

Creasy, K. T., Ren, H., Jiang, J., Peterson, M. L., & Spear, B. T. (2022). Elongation of Very Long Chain Fatty Acids Like-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression. bioRxiv.

Wilkerson, A., Bhat, N., Pham, H. Q. H., Yuksel, S., & Butovich, I. (2021). Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 35(2), e21327.

Yuksel, S., Wilkerson, A., McMahon, A., & Butovich, I. A. (2020). The roles of Elovl3 and Elovl4 in lipid homeostasis in Harderian glands of mice. Investigative Ophthalmology & Visual Science, 61(7), 2622-2622.

Wilkerson, A., Bhat, N., Yuksel, S., McMahon, A., Pham, H., & Butovich, I. A. (2020). Elongases of very long chain fatty acids-3 and 4 (ELOVL3 and ELOVL4) are essential for biosynthesis of meibum in mice. Investigative Ophthalmology & Visual Science, 61(7), 3227-3227.

Wilkerson, A., Bhat, N., McMahon, A., & Butovich, I. A. (2019). Elongase of very long chain fatty acids-3 (ELOVL3) is critical for meibum biosynthesis in mice. Investigative Ophthalmology & Visual Science, 60(9), 4194-4194.

Yang, Y., Liu, L., Li, M., Cheng, X., Fang, M., Zeng, Q., & Xu, Y. (2019). The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862(8), 834-845.

Butovich, I. A., Wilkerson, A., Bhat, N., McMahon, A., & Yuksel, S. (2019). On the pivotal role of Elovl3/ELOVL3 in meibogenesis and ocular physiology of mice. The FASEB Journal, 33(9), 10034-10048.

Chen, H., Gao, L., Yang, D., Xiao, Y., Zhang, M., Li, C., ... & Jin, Y. (2019). Coordination between the circadian clock and androgen signaling is required to sustain rhythmic expression of Elovl3 in mouse liver. Journal of Biological Chemistry, 294(17), 7046-7056.

Xu, J., Liu, D., Yin, H., Tong, H., Li, S., & Yan, Y. (2018). Fatty acids promote bovine skeletal muscle satellite cell differentiation by regulating ELOVL3 expression. Cell and tissue research, 373(2), 499-508.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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