ELOVL3

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

Full Name

ELOVL Fatty Acid Elongase 3

Research Area

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Biological Process

Alpha-linolenic acid metabolic process Source: Reactome
Fatty acid elongation, monounsaturated fatty acid Source: UniProtKB
Fatty acid elongation, polyunsaturated fatty acid Source: UniProtKB
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Linoleic acid metabolic process Source: Reactome
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

PTM

N-Glycosylated.