Mouse Anti-GPR34 Recombinant Antibody (CBFYH-0457) (CBMAB-H1331-FY)

Name: Mouse Anti-GPR34 Recombinant Antibody (CBFYH-0457)
SKU: CBMAB-H1331-FY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GPR34 Recombinant Antibody (CBFYH-0457) (CBMAB-H1331-FY) in IF

Representative immunofluorescence micrographs of iTF-Microglia on day 8 of differentiation stained for microglia markers GPR34 and IBA1. Nuclei were labeled by Hoechst 33342. Scale bar, 100 μm. ...View More

Dräger, N. M., Sattler, S. M., Huang, C. T., Teter, O. M., Leng, K., Hashemi, S. H., Hong, J., Aviles, G., Clelland, C. D., Zhan, L., Udeochu, J. C., Kodama, L., Singleton, A. B., Nalls, M. A., Ichida, J., Ward, M. E., Faghri, F., Gan, L., & Kampmann, M. (2022). A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature neuroscience, 25(9), 1149-1162. https://doi.org/10.1038/s41593-022-01131-4

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0457

Application

FC, IF, IHC

Immunogen

Human GPR34.

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor 34

Introduction

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.

Entrez Gene ID

2857

UniProt ID

Q9UPC5

Alternative Names

G Protein-Coupled Receptor 34; Probable G-Protein Coupled Receptor 34; LYPSR1

Function

Orphan receptor.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-61
Helical: 62-82
Cytoplasmic: 83-88
Helical: 89-109
Extracellular: 110-128
Helical: 129-149
Cytoplasmic: 150-171
Helical: 172-192
Extracellular: 193-216
Helical: 217-237
Cytoplasmic: 238-269
Helical: 270-290
Extracellular: 291-310
Helical: 311-331
Cytoplasmic: 332-381

Cheng, Y., Heng, X., & Feng, F. (2022). G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway. Technology in Cancer Research & Treatment, 21, 15330338221105733.

Zuo, B., Wu, N., Yang, S., Zhong, Z., Li, M., Yu, X., ... & Yu, W. (2022). G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN. Molecular Biology Reports, 1-11.

Yanhao Cheng, M. D., Xueyuan Heng, M. D., & Fan Feng, M. D. (2022). G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.

Tan, Y., Wang, H., & Zhang, C. (2021). MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells. Environmental Toxicology and Pharmacology, 81, 103514.

Wang, M., Tian, Y., Miao, L., & Zhao, W. (2021). MicroRNA-300 Inhibits the Proliferation and Metastasis of Cervical Cancer Cells via Posttranscriptional Suppression of G Protein-Coupled Receptor 34 (GPR34). Journal of Oncology, 2021.

Sayo, A., Konishi, H., Kobayashi, M., Kano, K., Kobayashi, H., Hibi, H., ... & Kiyama, H. (2019). GPR34 in spinal microglia exacerbates neuropathic pain in mice. Journal of Neuroinflammation, 16(1), 1-11.

Moody, S., Thompson, J. S., Chuang, S. S., Liu, H., Raderer, M., Vassiliou, G., ... & Du, M. Q. (2018). Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites. Haematologica, 103(8), 1329.

Schoeneberg, T., Meister, J., Knierim, A. B., & Schulz, A. (2018). The G protein-coupled receptor GPR34–the past 20 years of a grownup. Pharmacology & Therapeutics, 189, 71-88.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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