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Mouse Anti-EME1 Recombinant Antibody (7h2/1) (CBMAB-AP2053LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
7h2/1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human EME1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Essential Meiotic Structure-Specific Endonuclease 1
Introduction
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Entrez Gene ID
146956
UniProt ID
Q96AY2
Alternative Names
Essential Meiotic Structure-Specific Endonuclease 1; MMS4 Homolog; HMMS4; SLX2 Structure-Specific Endonuclease Subunit Homolog A (S. Cerevisiae); SLX2 Structure-Specific Endonuclease Subunit Homolog A; Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe); Essential Meiotic Endonuclease 1 Homolog 1; Essential Meiotic Endonuclease 1 Homolog 2;
Research Area
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Biological Process
Double-strand break repair Source: GO_Central
Mitotic intra-S DNA damage checkpoint signaling Source: GO_Central
Replication fork processing Source: GO_Central
Resolution of meiotic recombination intermediates Source: GO_Central
Response to intra-S DNA damage checkpoint signaling Source: MGI
Cellular Location
Nucleolus. Recruited to regions of DNA damage in S-phase cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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