EME1

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Essential Meiotic Structure-Specific Endonuclease 1

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Double-strand break repair Source: GO_Central
Mitotic intra-S DNA damage checkpoint signaling Source: GO_Central
Replication fork processing Source: GO_Central
Resolution of meiotic recombination intermediates Source: GO_Central
Response to intra-S DNA damage checkpoint signaling Source: MGI

Nucleolus. Recruited to regions of DNA damage in S-phase cells.