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Mouse Anti-EML4 Recombinant Antibody (CBFYE-0829) (CBMAB-E1283-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0829
Antibody Isotype
IgG1
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Echinoderm Microtubule Associated Protein Like 4
Introduction
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.
Entrez Gene ID
27436
UniProt ID
Q9HC35
Alternative Names
Echinoderm Microtubule Associated Protein Like 4; Restrictedly Overexpressed Proliferation-Associated Protein; Ropp 120; C2orf2; EMAP-4; EMAPL4; Echinoderm Microtubule-Associated Protein-Like 4; ROPP120; ELP120
Research Area
Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757).

Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526).

Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526).
Biological Process
Attachment of spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Microtubule-based process Source: UniProtKB
Microtubule cytoskeleton organization Source: GO_Central
Mitotic cell cycle Source: UniProtKB
Mitotic metaphase plate congression Source: UniProtKB
Cellular Location
Cytoskeleton; Spindle; Microtubule organizing center; Cytoplasm; Midbody. Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis.
PTM
Phosphorylated during mitosis (PubMed:16890222). Phosphorylation at Ser-144 and Ser-146 promotes its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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