Sign in or Register   Sign in or Register
  |  

Mouse Anti-EN2 (AA 18-333) Recombinant Antibody (CBFYE-0844) (CBMAB-E1299-FY)

This product is mouse antibody that recognizes EN2. The antibody CBFYE-0844 can be used for immunoassay techniques such as: ICC, WB.
See all EN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0844
Antibody Isotype
IgG2b
Application
ICC, WB

Basic Information

Immunogen
E.coli-derived recombinant human Engrailed2 Ser1 18-Glu333
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 18-333

Target

Full Name
engrailed homeobox 2
Introduction
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Entrez Gene ID
2020
UniProt ID
P19622
Alternative Names
Engrailed Homeobox 2; Homeobox Protein En-2; Hu-En-2; Homeobox Protein Engrailed-2; Engrailed Homolog 2; Engrailed-2
Biological Process
Embryonic brain development Source: Ensembl
Hindbrain development Source: Ensembl
Midbrain development Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of neuron apoptotic process Source: Ensembl
Neuron development Source: Ensembl
Neuron differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Genetic variations in EN2 may be associated with susceptibility to autism.

Poudel, P. P., Bhattarai, C., Ghosh, A., & Kalthur, S. G. (2022). Role of engrailed homeobox 2 (EN2) gene in the development of the cerebellum and effects of its altered and ectopic expressions. Egyptian Journal of Medical Human Genetics, 23(1), 1-7.

Phan, M. L., Liu, T. T., Vollbrecht, M. S., Mansour, M. H., Nikodijevic, I., Jadav, N., ... & Samuels, B. A. (2021). Engrailed 2 deficiency and chronic stress alter avoidance and motivation behaviors. Behavioural Brain Research, 413, 113466.

Cao, Y., Wang, X., Tang, L., Li, Y., Song, X., Liu, X., ... & Wan, H. (2020). Engrailed-2 promotes a malignant phenotype of esophageal squamous cell carcinoma through upregulating the expression of pro-oncogenic genes. PeerJ, 8, e8662.

Do Carmo Silva, J., Vesely, S., Novak, V., Luksanova, H., Prusa, R., & Babjuk, M. (2020). Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?. Biomarkers, 25(1), 34-39.

Li, Y., Liu, J., Xiao, Q., Tian, R., Zhou, Z., Gan, Y., ... & Yin, G. (2020). EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer. Cell death & disease, 11(7), 1-11.

Li, T., Yang, W., Li, M., Zhang, S., Zhou, X., Zuo, M., ... & Liu, Y. (2020). Engrailed 2 (EN2) acts as a glioma suppressor by inhibiting tumor proliferation/invasion and enhancing sensitivity to temozolomide. Cancer cell international, 20(1), 1-11.

Gómez-Gómez, E., Jiménez-Vacas, J. M., Pedraza-Arévalo, S., López-López, F., Herrero-Aguayo, V., Hormaechea-Agulla, D., ... & Luque, R. M. (2019). Oncogenic role of secreted engrailed homeobox 2 (EN2) in prostate cancer. Journal of clinical medicine, 8(9), 1400.

McGrath, S. E., Annels, N., Madhuri, T. K., Tailor, A., Butler-Manuel, S. A., Morgan, R., ... & Michael, A. (2018). Engrailed-2 (EN2)–a novel biomarker in epithelial ovarian cancer. BMC cancer, 18(1), 1-11.

Lin, X., Liu, X., & Gong, C. (2018). Expression of engrailed homeobox 2 regulates the proliferation, migration and invasion of non‑small cell lung cancer cells. Oncology letters, 16(1), 536-542.

Carratala-Marco, F., Andreo-Lillo, P., Martinez-Morga, M., Escamez-Martínez, T., Botella-López, A., Bueno, C., & Martinez, S. (2018). Clinical phenotypes associated to engrailed 2 gene alterations in a series of neuropediatric patients. Frontiers in neuroanatomy, 12, 61.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EN2 (AA 18-333) Recombinant Antibody (CBFYE-0844)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare