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Mouse Anti-ENOSF1 Recombinant Antibody (CBFYE-0886) (CBMAB-E1350-FY)

This product is mouse antibody that recognizes ENOSF1. The antibody CBFYE-0886 can be used for immunoassay techniques such as: ELISA, FC, IF, IHC-Fr, IHC-P, IP, WB.
See all ENOSF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0886
Antibody Isotype
IgG1
Application
ELISA, FC, IF, IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant Thymidylate Synthase
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ENOSF1
Introduction
This gene can encode a mitochondrial enzyme that is thought to convert L-fuconate to 2-keto-3-deoxy-L-fuconate. This locus was originally identified as the source of antisense RNAs of the adjacent thymidylate synthase gene. Splice variants at this locus may contain an alternate 3' exon that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and may downregulate TS expression.
Entrez Gene ID
55556
UniProt ID
Q7L5Y1
Alternative Names
Enolase Superfamily Member 1; Antisense RNA To Thymidylate Synthase; L-Fuconate Dehydratase; TYMSAS; RTS; Mitochondrial Enolase Superfamily Member 1; EC 4.2.1.68
Research Area
Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).
Biological Process
Carbohydrate catabolic process Source: GO_Central
Cellular amino acid catabolic process Source: InterPro
Cellular carbohydrate catabolic process Source: UniProtKB
Cellular Location
Mitochondrion
PTM
Could be sumoylated.

Cura, Y., Pérez-Ramírez, C., Sánchez-Martín, A., Cuenca, M. C., & Jimenez-Morales, A. (2022). 4CPS-059 Case report of severe hyperbilirrubinaemia in a patient carrying polymorphisms in CES1P1, CDA, SLC22A7 and ENOSF1 treated with fluoropyrimidines.

Fernandes, M. R., Costa, D. F. D., Barra, W. F., Rodrigues, J. C. G., Gonçalves, M. A. B., Fontoura, R. M., ... & Santos, N. P. C. D. (2022). Investigation of the DPYD, TYMS, ENOSF1, MTHFR, CDA, CES2, and UGT1A1 genes in patients who developed fatal fluoropyrimidine-associated toxicity in Northern Brazil.

Palles, C., Fotheringham, S., Chegwidden, L., Lucas, M., Kerr, R., Mozolowski, G., ... & Kerr, D. (2021). An Evaluation of the Diagnostic Accuracy of a Panel of Variants in DPYD and a Single Variant in ENOSF1 for Predicting Common Capecitabine Related Toxicities. Cancers, 13(7), 1497.

Hamzic, S., Kummer, D., Froehlich, T. K., Joerger, M., Aebi, S., Palles, C., ... & Largiadèr, C. R. (2020). Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis. Pharmacological research, 152, 104594.

Palles, C., Fotheringham, S., Chegwidden, L., Lucas, M., Mozolowski, G., Tomlinson, I., & Kerr, D. (2018). An evaluation of the clinical utility of a panel of variants in DPYD and ENOSF1 for predicting common capecitabine related toxicities. Annals of Oncology, 29, v59-v60.

Kelemen, L. E., Earp, M., Fridley, B. L., Chenevix-Trench, G., Australian Ovarian Cancer Study Group, Fasching, P. A., ... & Ovarian Cancer Association Consortium. (2018). rs495139 in the TYMS-ENOSF1 region and risk of ovarian carcinoma of mucinous histology. International journal of molecular sciences, 19(9), 2473.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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