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Mouse Anti-EPC1 (AA 695-798) Recombinant Antibody (CBFYE-0934) (CBMAB-E1411-FY)

This product is mouse antibody that recognizes EPC1. The antibody CBFYE-0934 can be used for immunoassay techniques such as: ELISA.
See all EPC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0934
Antibody Isotype
IgM, κ
Application
ELISA

Basic Information

Immunogen
EPC1 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: KGLHLSSTTP TALVHTSPST AGSALLQPSN ITQTSSSHSA LSHQVTAANS ATTQVLIGNN IRLTVPSSVA TVNSIAPINA RHIPRTLSAV PSSALKLAAA ANCQ
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 695-798

Target

Full Name
ENHANCER OF POLYCOMB HOMOLOG 1
Introduction
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
80314
UniProt ID
Q9H2F5
Alternative Names
Enhancer Of Polycomb Homolog 1; Enhancer Of Polycomb Homolog 1 (Drosophila); Epl1
Research Area
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
Biological Process
Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Negative regulation of gene expression, epigenetic Source: MGI
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription, DNA-templated Source: UniProtKB
Vascular associated smooth muscle cell differentiation Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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