EPC1

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.

Full Name

ENHANCER OF POLYCOMB HOMOLOG 1

Research Area

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Biological Process

Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Negative regulation of gene expression, epigenetic Source: MGI
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription, DNA-templated Source: UniProtKB
Vascular associated smooth muscle cell differentiation Source: Ensembl

Cellular Location

Nucleus