Mouse Anti-EPC1 Recombinant Antibody (CBFYE-0933) (V2LY-0825-LY376)

Name: Mouse Anti-EPC1 Recombinant Antibody (CBFYE-0933)
SKU: V2LY-0825-LY376
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0933

Application

WB, IP, IF, IHC-P, ELISA

Immunogen

Amino acids 683-785 mapping near the C-terminus of human EPC1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ENHANCER OF POLYCOMB HOMOLOG 1

Entrez Gene ID

80314

UniProt ID

Q9H2F5

Research Area

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Biological Process

Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Negative regulation of gene expression, epigenetic Source: MGI
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription, DNA-templated Source: UniProtKB
Vascular associated smooth muscle cell differentiation Source: Ensembl

Cellular Location

Nucleus

Dai, Y., Chen, W., Huang, C., Luo, S., Huang, J., Xu, J., ... & Chen, L. (2021). Expression and Biological Functions of EPC1 in Nasopharyngeal Carcinoma. Archives of Iranian Medicine, 24(11), 845-851.

Zhang, H., Devoucoux, M., Song, X., Li, L., Ayaz, G., Cheng, H., ... & Min, J. (2020). Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex. Cell reports, 30(12), 3996-4002.

Gu, X. H., Lin, H. R., & Xia, J. H. (2018). Significant association of SNP polymorphism in the tilapia enhancer of polycomb homolog 1 gene with salt tolerance. Aquaculture Research, 49(4), 1690-1698.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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