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Mouse Anti-ACVR1C Recombinant Antibody (V2-179685) (CBMAB-A1041-YC)

Provided herein is a Mouse monoclonal antibody against Human Activin A Receptor Type 1C. The antibody can be used for immunoassay techniques, such as FC.
See all ACVR1C antibodies
Published Data
Mouse Anti-ACVR1C Recombinant Antibody (CBYC-A280) (CBMAB-A1041-YC) in FC
The membrane bound expression level of various growth factor receptors determined by flow cytometry in human pancreatic cancer cell lines represented as histograms. EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; c-MET, mesenchymal-epithelial transition factor; IGF-IR, insulin-like growth factor 1 receptor; ALK7, anaplastic lymphoma kinase 7. ...View More
Khan, T., Seddon, A. M., Dalgleish, A. G., Khelwatty, S., Ioannou, N., Mudan, S., & Modjtahedi, H. (2020). Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer. Oncology Reports, 44(6), 2581-2594.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179685
Antibody Isotype
IgG2b
Application
IHC-F, WB

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ALK‑7 Leu26-Glu113.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC2.5 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Activin A Receptor Type 1C
Introduction
ACVR1C is a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with oth
Entrez Gene ID
130399
UniProt ID
Q8NER5
Alternative Names
Activin A Receptor Type 1C; Activin Receptor-Like Kinase 7; Activin A Receptor, Type IC; Activin Receptor Type IC; EC 2.7.11.30; ACTR-IC;
Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Biological Process
Activin receptor signaling pathway
Apoptotic nuclear changes
Cell differentiation
Cellular response to growth factor stimulus
Lipid storage
Negative regulation of chorionic trophoblast cell proliferation
Negative regulation of insulin secretion
Negative regulation of trophoblast cell migration
Nervous system development
Nodal signaling pathway
Positive regulation of apoptotic process
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Protein phosphorylation
Response to dietary excess
Response to glucose
Response to insulin
Trophectodermal cell proliferation
Cellular Location
Membrane
Topology
Extracellular: 22-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-493 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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