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Mouse Anti-ACVR1C Recombinant Antibody (V2-610967) (CBMAB-A0110-LY)

The product is antibody recognizes ACVR1C. The antibody 2E3 immunoassay techniques such as: ELISA.
See all ACVR1C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-610967
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
ACVR1C (AAH22530.1, 23 a.a. ~ 112 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
In situ Proximity Ligation Assay (Cell)1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Activin A Receptor Type 1C
Introduction
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM
Entrez Gene ID
130399
Alternative Names
ACVRLK7; ALK7
Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Biological Process
Activin receptor signaling pathway
Apoptotic nuclear changes
Cell differentiation
Cellular response to growth factor stimulus
Lipid storage
Negative regulation of chorionic trophoblast cell proliferation
Negative regulation of insulin secretion
Negative regulation of trophoblast cell migration
Nervous system development
Nodal signaling pathway
Positive regulation of apoptotic process
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Protein phosphorylation
Response to dietary excess
Response to glucose
Response to insulin
Trophectodermal cell proliferation
Cellular Location
Membrane
Topology
Extracellular: 22-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-493 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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