What is the recommended storage condition for this antibody?

For short-term storage (1-2 weeks), it is recommended to keep the antibody at +4°C. For long-term storage, you should aliquot the antibody into smaller volumes and store it at -20°C. Avoid repeated freeze-thaw cycles as this can degrade the antibody.

What applications is this antibody validated for?

This Mouse Anti-ACVR1C Recombinant Antibody (V2-610967) has been validated for use in a variety of applications including Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), and ELISA. Detailed protocols and recommended dilutions for each application are provided in the product datasheet to ensure successful experimental outcomes.

Mouse Anti-ACVR1C Recombinant Antibody (V2-610967) (CBMAB-A0110-LY)

See all ACVR1C antibodies

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-610967

Application

ELISA

Immunogen

ACVR1C (AAH22530.1, 23 a.a. ~ 112 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
In situ Proximity Ligation Assay (Cell)	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Activin A Receptor Type 1C

Introduction

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM

Entrez Gene ID

130399

Alternative Names

ACVRLK7; ALK7

Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Biological Process

Activin receptor signaling pathway
Apoptotic nuclear changes
Cell differentiation
Cellular response to growth factor stimulus
Lipid storage
Negative regulation of chorionic trophoblast cell proliferation
Negative regulation of insulin secretion
Negative regulation of trophoblast cell migration
Nervous system development
Nodal signaling pathway
Positive regulation of apoptotic process
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Protein phosphorylation
Response to dietary excess
Response to glucose
Response to insulin
Trophectodermal cell proliferation

Cellular Location

Membrane

Topology

Extracellular: 22-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-493 aa

Tian, Y. D., Chung, M. H., Quan, Q. L., Lee, D. H., Kim, E. J., & Chung, J. H. (2021). UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes. International Journal of Molecular Sciences, 22(3), 1101.

Lebid, A. (2020). Activin A promotes Treg induction in cancer through the Activin Receptor 1C (Doctoral dissertation, Johns Hopkins University).

Asnaghi, L., White, D. T., Key, N., Choi, J., Mahale, A., Alkatan, H., ... & Eberhart, C. G. (2019). ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma. Oncogene, 38(12), 2056-2075.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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