Human Recombinant ACVR1C protein, ECD, hFc Tag (V2LY-0526-LY2029)

Name: Human Recombinant ACVR1C protein, ECD, hFc Tag
SKU: V2LY-0526-LY2029
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant ACVR1C protein, ECD, hFc Tag consist of Amino Acid: 1-113 and predicts a molecular mass of 36.6 kDa.

Molecule Mass

36.6 kDa

Protein Domain

ECD

Sequence

Amino Acid: 1-113

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Activin A Receptor Type 1C

Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Biological Process

Activin receptor signaling pathway
Apoptotic nuclear changes
Cell differentiation
Cellular response to growth factor stimulus
Lipid storage
Negative regulation of chorionic trophoblast cell proliferation
Negative regulation of insulin secretion
Negative regulation of trophoblast cell migration
Nervous system development
Nodal signaling pathway
Positive regulation of apoptotic process
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Protein phosphorylation
Response to dietary excess
Response to glucose
Response to insulin
Trophectodermal cell proliferation

Cellular Location

Membrane

Topology

Extracellular: 22-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-493 aa

Tian, Y. D., Chung, M. H., Quan, Q. L., Lee, D. H., Kim, E. J., & Chung, J. H. (2021). UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes. International Journal of Molecular Sciences, 22(3), 1101.

Lebid, A. (2020). Activin A promotes Treg induction in cancer through the Activin Receptor 1C (Doctoral dissertation, Johns Hopkins University).

Asnaghi, L., White, D. T., Key, N., Choi, J., Mahale, A., Alkatan, H., ... & Eberhart, C. G. (2019). ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma. Oncogene, 38(12), 2056-2075.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ACVR1C protein, ECD, hFc Tag-1 (CAT#: V2LY-0526-LY2030)

Human Recombinant ACVR1C protein, GST Tag (CAT#: V2LY-0526-LY2031)

Human Recombinant ACVR1C protein, Fc Tag (CAT#: V2LY-0526-LY2032)

Mouse Recombinant ACVR1C protein, hFc Tag (CAT#: V2LY-0526-LY7792)

Rhesus Recombinant ACVR1C protein, hFc Tag (CAT#: V2LY-0526-LY9645)

Related Products

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Rhesus Recombinant ACVR1C protein, hFc Tag (CAT#: V2LY-0526-LY9645)

Mouse Anti-ACVR1C Recombinant Antibody (V2-179688) (CAT#: CBMAB-A1044-YC)

Mouse Anti-ACVR1C Recombinant Antibody (V2-610967) (CAT#: CBMAB-A0110-LY)

Human Recombinant ACVR1C protein, GST Tag (CAT#: V2LY-0526-LY2031)

Mouse Recombinant ACVR1C protein, hFc Tag (CAT#: V2LY-0526-LY7792)

Human Recombinant ACVR1C protein, Fc Tag (CAT#: V2LY-0526-LY2032)

Mouse Anti-ACVR1C Recombinant Antibody (V2-179687) (CAT#: CBMAB-A1043-YC)

Human Recombinant ACVR1C protein, ECD, hFc Tag-1 (CAT#: V2LY-0526-LY2030)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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